Pediatric Neuro-oncology Cell Atlas
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Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high grade glioma
Background Pediatric high-grade gliomas (PHGG) are aggressive brain tumors with five-year survival rates ranging from less than 2% to …
John DeSisto
,
Andrew M Donson
,
Andrea M Griesinger
,
Rui Fu
,
Kent Riemondy
,
Jean Mulcahy Levy
,
Julie A Siegenthaler
,
Nicholas K Foreman
,
Rajeev Vibhakar
,
Adam L Green
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Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas
Plexiform neurofibroma (PN) is a leading cause of morbidity in children with the genetic condition Neurofibromatosis Type 1 (NF1), …
Vladimir Amani
,
Kent A Riemondy
,
Rui Fu
,
Andrea M Griesinger
,
Enrique Grimaldo
,
Graziella Ribeiro De Sousa
,
Ahmed Gilani
,
Molly Hemenway
,
Nicholas K Foreman
,
Andrew M Donson
,
Nicholas Willard
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Multi-Omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high risk pediatric ependymoma
SummaryEpendymoma (EPN) is a devastating childhood brain tumor. Single-cell analyses have illustrated the cellular heterogeneity of EPN …
Andrea M Griesinger
,
Kent Riemondy
,
Nithyashri Eswaran
,
Andrew M Donson
,
Nicholas Willard
,
Eric W Prince
,
Simon M L Paine
,
Georgia Bowes
,
John Rheaume
,
Rebecca J Chapman
,
Judith Ramage
,
Andrew Jackson
,
Richard G Grundy
,
Nicholas K Foreman
,
Timothy A Ritzmann
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Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: a multicenter study
BACKGROUND: Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN …
Andrew M Donson
,
Kelsey C Bertrand
,
Kent A Riemondy
,
Dexiang Gao
,
Yonghua Zhuang
,
Bridget Sanford
,
Gregory A Norris
,
Rebecca J Chapman
,
Rui Fu
,
Nicholas Willard
,
Andrea M Griesinger
,
Graziella Ribeiro De Sousa
,
Vladimir Amani
,
Enrique Grimaldo
,
Todd C Hankinson
,
Ffyona Booker
,
Martin Sill
,
Richard G Grundy
,
Kristian W Pajtler
,
David W Ellison
,
Nicholas K Foreman
,
Timothy A Ritzmann
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Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma
BACKGROUND: The diverse cellular constituents of childhood brain tumor ependymoma, recently revealed by single cell RNA-sequencing, may …
Rui Fu
,
Gregory A Norris
,
Nicholas Willard
,
Andrea M Griesinger
,
Kent A Riemondy
,
Vladimir Amani
,
Enrique Grimaldo
,
Faith Harris
,
Todd C Hankinson
,
Siddhartha Mitra
,
Timothy A Ritzmann
,
Richard R Grundy
,
Nicholas K Foreman
,
Andrew M Donson
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Neoplastic and immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma
BACKGROUND: Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells and associated immune cells contribute to disease …
Kent A Riemondy
,
Sujatha Venkataraman
,
Nicholas Willard
,
Anandani Nellan
,
Bridget Sanford
,
Andrea M Griesinger
,
Vladimir Amani
,
Siddhartha Mitra
,
Todd C Hankinson
,
Michael H Handler
,
Martin Sill
,
Jennifer Ocasio
,
Seth J Weir
,
Daniel S Malawsky
,
Timothy R Gershon
,
Alexandra Garancher
,
Robert J Wechsler-Reya
,
Jay R Hesselberth
,
Nicholas K Foreman
,
Andrew M Donson
,
Rajeev Vibhakar
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Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology
Summary Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular …
Austin E Gillen
,
Kent A Riemondy
,
Vladimir Amani
,
Andrea M Griesinger
,
Ahmed Gilani
,
Sujatha Venkataraman
,
Krishna Madhavan
,
Eric Prince
,
Bridget Sanford
,
Todd C Hankinson
,
Michael H Handler
,
Rajeev Vibhakar
,
Ken L Jones
,
Siddhartha Mitra
,
Jay R Hesselberth
,
Nicholas K Foreman
,
Andrew M Donson
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