Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations

We utilized single cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), and cytokine analyses to characterize and help better understand tumor and immune cell heterogeneity across pLGG tumors.

Data availability

scRNA-seq and spatial transcriptomics data have been deposited in the National Center for Biotechnology Information Gene Expression Omnibus (GEO) database and will be released upon publication.

A UCSC cell browser, currently private, will be made available for interactive exploration of the data upon publication.

Supported by

Alex’s Lemonade Stand Foundation
Morgan Adams Foundation
Olivia Caldwell Foundation
Amazon Goes Gold
Colorado Clinical and Translational Sciences Institute (CCTSI)
University of Colorado’s NIH/NCI Cancer Center (P30CA046934)